Weisbuch studied at the Beaux-arts de Nancy (today's L'École nationale supérieure d'art de Nancy), and excelled at every type of lithograph making. Around 1951, he started making his career through exhibitions in varioussalons. In 1961, he won the Critics' Prize. He was adept at portraying human figures, horses, and opera. After the
1960s, Weisbuch gradually developed his own style and sense of brush, reducing the use of colors while making the strokes smoother. He often chose performances with musical instruments, hunchbacked clowns in Italian masquerades as subjects of his paintings. He used unique strokes to express bodily movement. The dynamic parts resemble repeated exposures of a camera; through this, the artist captures movement giving his work a unique touch. Being an important contemporary French artist, Weisbuch’s works in widely collected by major institutions and museums of the world, including New York Modern Museum of Art, Centre Pompidou in Paris, Academie Royale in Belgium and more.